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Página de Inicio arrow Artículos Científicos arrow Efficacy and Safety of Spinosad and Permethrin Creme Rinses for Pediculosis Capitis (Head Lice).
Efficacy and Safety of Spinosad and Permethrin Creme Rinses for Pediculosis Capitis (Head Lice). Imprimir E-Mail
Dow Stough, MDa, Susan Shellabarger, MSb, John Quiring, PhDc and Alvin
A. Gabrielsen, Jr, MDd. Efficacy and Safety of Spinosad and Permethrin
Creme Rinses for Pediculosis Capitis (Head Lice).PEDIATRICS Vol. 124
No. 3 September 2009, pp. e389-e395



OBJECTIVE: Studies compared spinosad creme rinse and permethrin lice
treatment under "actual-use" conditions for pediculosis capitis (head
lice).

SUBJECTS AND MATERIALS: Two phase-3, multicenter, randomized,
evaluator/investigator-blinded studies compared 0.9% spinosad without
nit-combing to 1% permethrin with combing (according to product
instructions) in 1038 males and females aged 6 months.
Spinosad-with-combing groups were included for descriptive,
noninferential purposes only. Within 391 households, youngest members
having 3 live lice were designated primary participants. All household
members with lice received the same treatment. Participants
administered product 1 to 2 times during the 21-day home-use period on
the basis of complete lice eradication after a single use or the
presence of lice requiring a second treatment. Scalp evaluations were
performed at baseline, day 7, and day 14 (and day 21 for participants
treated twice). The primary end point was the proportion of lice-free
primary participants 14 days after last treatment.

RESULTS: A total of 84.6% (study 1) and 86.7% (study 2) of
spinosad-treated participants were lice free versus 44.9% and 42.9%
permethrin-treated participants (P < .001). Most spinosad-treated
participants required 1 application, whereas most permethrin-treated
participants required 2 applications. Few adverse events were
reported, but those occurring were mild to moderate, including eye
irritation (permethrin), ocular hyperemia, and application-site
erythema/irritation (both medications). No laboratory measure changed
significantly.

CONCLUSIONS: Spinosad, which did not require nit combing, was
significantly more effective than permethrin in 2 studies reflecting
actual-use conditions, and most spinosad-treated participants required
only 1 application. Spinosad is a more convenient and effective
treatment for pediculosis capitis.
 
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