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Página de Inicio arrow Artículos Científicos arrow Tacrolimus ointment does not affect the immediate response to vaccination, the generation of immune
Tacrolimus ointment does not affect the immediate response to vaccination, the generation of immune Imprimir E-Mail
T Hofman1, N Cranswick2, P Kuna3, A Boznanski4, T Latos5, M Gold6, D F Murrell7, K Gebauer8, U Behre9, E Machura10, J Ólafsson11, Z Szalai12 on behalf of the International Tacrolimus Ointment Study Group*
1 Allergy Centre, Poznan, Poland
2 Paediatric Pharmacology Research Unit, Royal Children's Hospital, Parkville, Victoria, Australia
3 Division of Pneumonology and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
4 I Katedra Pediatrii Klinika Alergologii I Kardiologii, Wroclawska Akademia Medyczna, Wroclaw, Poland
5 Centrum Pulmonologii Dzieciecej, Karpacz, Poland
6 Department of Paediatrics, Women's and Children's Hospital, North Adelaide, Adelaide, Australia
7 Dermatology Department, St George Hospital, University of New South Wales, Sydney, New South Wales, Australia
8 Fremantle Dermatology Clinic, Fremantle, Western Australia, Australia
9 Hauptstr 240, Kehl, Germany
10 Oddzial Pulmonologii I Alergologii, Slaskie Centrum Pediatrii, Zabrze, Poland
11 Hudlaeknastödin, Kopavogur, Iceland
12 Department of Dermatology, Heim Pal Children's Hospital, Budapest, Hungary


Correspondence to:
T Hofman
Allergy Centre, Boguslawskiego 16a, 60-214 Poznan, Poland; Esta dirección de correo electrónico está protegida contra los robots de spam, necesita tener Javascript activado para poder verla

Background: Concern exists that the prolonged application of immunomodulators to treat atopic dermatitis may cause systemic immunosuppression.

Aims: In a 7-month, multicentre, randomised, controlled trial, we investigated the equivalence of response to vaccination against meningococcal serogroup C disease with a protein-conjugate vaccine in children (2-11 years) with moderate to severe atopic dermatitis, by applying either 0.03% tacrolimus ointment (TAC-O; n = 21) or a hydrocortisone ointment regimen (HC-O; n = 111).

Methods: TAC-O was applied twice daily (bid) for 3 weeks, and thereafter daily until clearance. 1% hydrocortisone acetate (HA) for head/neck and 0.1% hydrocortisone butyrate ointment for trunk/limbs was applied bid for 2 weeks; thereafter HA was applied bid to all affected areas. At week 1, patients were vaccinated with protein-conjugate vaccine against meningococcal serogroup C, and challenged at month 6 with low dose meningococcal polysaccharide vaccine. The control group (44 non-atopic dermatatits children) received the primary vaccination and challenge dose. Assessments were made at baseline, weeks 1 and 5, and months 6 and 7. The primary end point was the percentage of patients with a serum bactericidal antibody (SBA) titre 8 at the week 5 visit.

Results: The response rate (patients with SBA titre 8) was 97.5% (confidence interval (CI) approximately 97.3 to 100), 99.1% (94.8 to 100) and 97.7% (93.3 to 100) in the TAC-O, HC-O and control groups, respectively.

Conclusions: The immune response to vaccination against meningococcal serogroup C in children with atopic dermatitis applying either 0.03% TAC-O or HC is equivalent. Ointment application does not affect the immediate response to vaccination, generation of immune memory or humoral and cell-mediated immunity.
 
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